Students of Serra Catholic have been accepted to the following institutions:

Alderson-Broaddus College
Allegheny College
American University
The Apprentice School (Northrop Grumman Shipbuilding)
Art Institute of Pittsburgh
Bethany College
Bradford School
California University of Pennsylvania
Carlow University
Carnegie Mellon University
Case Western Reserve University
Catholic University
Centenary College of Louisiana
Colgate University
College of Wooster
Clarion University
Community College of Allegheny County (Boyce/South)
DePaul University
Drexel University
Duquesne University
Edinboro University
Embry-Riddle Aeronautical University
Franciscan University of Steubenville
Gannon University
Geneva College
Georgetown University
Georgia Institute of Technology
George Mason University
Grove City College
Indiana University of Pennsylvania
John Carroll University
Kennesaw University
Kent State University
Kenyon College
LaRoche College
Marymount University
Mercyhurst College
Niagara University
Notre Dame University
Penn State Greater Allegheny
Penn State University Park
Philadelphia University
Pittsburgh Institute of Mortuary Science
Point Park University
Providence College
Rensselaer Polytechnic Institute
Robert Morris University
Rochester Institute of Technology
Saint Francis University
Saint Vincent College
Salem International University
Seton Hill University
Slippery Rock University
Syracuse University
Temple University
Thiel College
University of Akron
University of Central Florida
University of Cincinnati
University of Dayton
University of Delaware
University of Pittsburgh at Greensburg
University of Pittsburgh at Johnstown
University of Pittsburgh at Oakland
University of Toledo
Washington and Jefferson College
Waynesburg University
Westminster College
West Virginia University
Wheeling Jesuit University
Villanova University
Youngstown State University